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Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.A comprehensive review with 185 references for the analysis of commonly prescribed members of an important class of drugs, non-sedating antihistamines (NSAs), is presented.The review covers most of the methods described for the analysis of cetirizine (CTZ), ebastine (EBS), fexofenadine (FXD), ketotifen (KET) and loratadine (LOR) in pure forms, in different pharmaceutical dosage forms and in biological fluids. It could be something as simple as a run away script or learning how to better use E-utilities, for more efficient work such that your work does not impact the ability of other researchers to also use our site.To restore access and understand how to better interact with our site to avoid this in the future, please have your system administrator contact [email protected]

Many antihistamines are also commonly taken for motion sickness. This means it has an effect on small blood vessels, resulting in dilated capillaries (redness), and leakage of protein-rich fluid into surrounding skin (swelling).Histamine affects nearby nerves resulting in itching.Topical preparations (ointments and creams) are often applied to insect bites but are not very effective as the antihistamine chemical does not penetrate the skin well.Sedating antihistamines should not be used in children under the age of 2 years for any reason and should not be used in children under 6 years for cough and cold symptoms.

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